Dose of vancomycin

Vancocin (vancomycin) dosing, indications, interactions

Indicated for treatment of early-onset prosthetic valve endocarditis caused by Staphylococcus epidermidis in combination with rifampin and an aminoglycoside. Usual dosage: 2 g divided either as 500.. o Loading dose: 25-30 mg/kg x 1, maintenance dose should follow at suggested interval Weight (kg) Dose (grams) 50-64 1.5 x 1 dose 65-79 1.75 x 1 dose 80-94 2 x 1 dose > 95 2.5 x 1 dose Maintenance Doses . o. Follow below algorithm for initial vancomycin doses based on weight and renal function . Last updated: 4/201

vancomycin doses Traditional Dosing: goal trough 10-15 mcg/mL High Dosing: goal trough 15-20 mcg/mL Weight (kg) Maintenance Dose ~ 12.5 to 15mg/kg / dose Maintenance Dose ~ 15mg/kg / dose So per the guidelines, if a loading dose is clinically appropriate, you should use an actual body weight-based dose of 20-25 mg/kg, but cap the dose at 3000 mg. Since empiric maintenance doses depend on vancomycin clearance, which typically doesn't exceed a certain level in obese patients, it's also recommended to stay below 4500 mg/day vancomycin plasma trough sample should be taken approximately 48hrs after initiation of therapy (3rd Day) and timed to coincide with morning pathology rounds and within 30 minutes prior to the morning dose. Routine levels should be ordered no more than twice weekly if stable and within target range. Follow up levels subsequent to a dose adjustment should be ordered 36-48 hours after the new dosing regimen has started Current clinical practice is to administer vancomycin as a stat dose of 1000milligrams and closely monitor. Vancomycin level should be obtained 24 hours after the first dose is given. The patient can be re-prescribed a stat dose when the vancomycin trough concentration is below 20mg/L The 2020 vancomycin dosing guidelines offer some clear guidance regarding loading doses and maximum doses: For non-obese adult patients with normal renal function, a loading dose of 20-35mg/kg (maximum dose: 3000mg) is recommended

Oral (taken by mouth) vancomycin fights bacteria in the intestines. Vancomycin is used to treat an infection of the intestines caused by Clostridium difficile, which can cause watery or bloody diarrhea. This medicine is also used to treat staph infections that can cause inflammation of the colon and small intestines Vancomycin Loading Dose In selected patients, a loading dose (25-30 mg/kg of total body weight; maximum 3000 mg) may be considered in order to achieve rapid attainment of serum concentrations. 12 Patients who should be considered for a loading dose include those who are critically-ill, those receiving renal replacement therapy, or those receiving a continuous infusion of vancomycin Each vancomycin dose goes through a process where it is administered intravenously, which causes the serum level to increase. Then the vancomycin is distributed out of the blood and into the tissues. The blood and the tissues reach a sort of equilibrium In patients undergoing intermittent hemodialysis, vancomycin IV is given on dialysis days, typically 3 times a week Give the first dose of vancomycin the day it is ordered and subsequent doses on dialysis days Vancomycin doses are administered during the last portion of the hemodialysis session (intradialytic administration) or after hemodialysi Fifteen mg/kg initial dosage of vancomycin was administered intravenously every 12 h lasted for 2 hrs in the critically ill patients. Serum vancomycin concentrations were measured by the fluorescence polarization immunoassay method using an Integra700 or a Cobas6000 c501 analyzer (Roche Diagnostics, Shanghai, China)

Dosing of IV Vancomycin In March 2020, new vancomycin dosing guidelines from leading infectious disease and pharmacy groups were released. Non-obese adult patients with normal kidney function begin with a dosing of 15 to 20 mg/kg IV (based on the patient's actual body weight), given every 8 to 12 hours Initiating vancomycin treatment with a continuous infusion: Loading dose 20-30 mg/kg is given over 1 hour followed by a continuous infusion. The usual starting dose is 60 mg/kg/day. Therapeutic drug monitoring. Target steady state level: 15-25 mg/L young infants (0-90 days of age) 20-25 mg/L children (>90 days of age Vancomycin distributes pretty darn well throughout the body. Population kinetics estimates a volume of distribution (Vd) of ~0.7 L/kg. Because of this distribution, we dose vancomycin based on total (actual) body weight in non-obese patients. In obese patients, consider use of adjusted body weight instead and/or lowering the Vd estimate (0.5-0.6 L/kg) Vancomycin maintenance dose and monitoring Creatinine clearance (mL/min) Maintenance dose Start time after loading dose and dosing interval Volume of sodium chloride 0.9% or glucose 5% Infusion time Infusion rate Time of first vancomycin trough level >110 1.5g 12 hours 500mL 180min 167mL/hr Before.

Variable vancomycin dosages (ranging from 5 to 40 mg/kg per day) with different dosing intervals (every 6, 8, 12, or 24 h) were used, depending on the severity of infectious disease. Blood samples were obtained ~0.5-1 h before or after the third or fourth dose Obtain a vancomycin level and dose per level Monitor random levels in patients and re-dose when level <15 mcg/mL Monitoring after 48 hours of starting vancomycin: 1. Use the following table to guide monitoring of vancomycin based on the patient's clinical status: Clinical Situation Monitoring Recommendatio 45 The average amount of vancomycin removed by high flux HD during a 3- to 4-hour session is 30 to 38%.46. 7.1. Most patients will require a vancomycin dose after each dialysis session. One method for dosing patients on a regular HD schedule (of three times per week) is to give an initial loading dose of The dose of vancomycin required is dependent on the type and severity of infection, the patient's overall clinical presentation, renal function, and body weight. The desired intravenous dose should be administered slowly over at least 60 minutes Vancomycin tapers should begin after the treatment course is completed. Example of PO vancomycin taper: 125 mg PO BID x7 days, then 125 mg PO daily x7 days, then 125 mg PO every other day x7 days, then 125 mg PO every 3 days x2-8 weeks. Patients on tapered doses of PO vancomycin should continue to be monitored for signs and symptoms of C. difficile disease

Dose adjustment has led to a disproportionate increase in vancomycin level (e.g. 20% dose increase should increase vancomycin level by 20%, but if level has increased by 50% this would not be proportional) Discontinuation of vancomycin and alternative therapy should be considered after consultation with th Vancomycin is a glycopeptide antibiotic administered intravenously for treatment of patients with suspected or proven invasive gram-positive infections, including methicillin-resistant Staphylococcus aureus. Appropriate dosing and administration of vancomycin requires consideration of the pathogen, type and severity of infection, patient weight. Background: While vancomycin loading doses may facilitate earlier pharmacokinetic-pharmacodynamic target attainment, the impact of loading doses on clinical outcomes remains understudied. Critically ill patients are at highest risk of morbidity and mortality from methicillin resistant Staphylococcus aureus (MRSA) infection and hypothesized to most likely benefit from a loading dose

Vancomycin Trough Frequency/Timing (Adults, NEONATES, AND Pediatrics): o Timing in Relation to Dose: Draw trough within 30 minutes prior to the next dose. o Initial Troughs: Obtain trough when vancomycin steady state is achieved (i.e. just prior to 4th dose of vancomycin (including loading dose)) For oral dosage forms (capsules or oral liquid): For treatment of C. difficile-associated diarrhea: Adults—125 milligrams (mg) 4 times a day for 10 days. Children—Dose is based on body weight and must be determined by the doctor. The usual dose is 40 milligrams per kilogram (mg/kg) of body weight, divided into 3 or 4 doses, and taken for 7. Vancomycin is used to a treat a bacterial infection in your bowel caused by Clostridium difficile (C. difficile).Infection with C. difficile most commonly occurs in people who have recently had a course of antibiotics and are in hospital.. Some people have small numbers of C. difficile germs (bacteria) which live in their bowels, and they usually do no harm

15-20 mg/kg every 8-12 hours (max. per dose 2 g) adjusted according to plasma-concentration monitoring, duration should be tailored to type and severity of infection and the individual clinical response—consult product literature for further information, in seriously ill patients, a loading dose of 25-30 mg/kg (usual max. 2 g) can be used to facilitate rapid attainment of the target trough serum-vancomycin concentration Serum vancomycin level taken towards the end of the dosing interval, approximately one hour prior to next dose . 4. Loading dose Based on the currently available evidence, clinical data support a loading dose of 25mg / kg (actual body weight) [3]. A loading dose will facilitate more rapid attainment of therapeutic target range [4]. Highe Vancomycin 1 gm IV x1 provides sub-therapeutic levels for patients with normal renal function. Efficacy is based on overall exposure (e.g., AUC/MIC) achieved with repeated dosing over several days. Subtherapeutic vancomycin concentrations lead to development of resistance. Despite the above points, a one-time dose of vancomycin prior to the. The desired dose diluted in this manner should be administered by intravenous infusion over a period of at least 60 minutes. Vancomycin solution has a low pH and may cause physical instability of other compounds. Mixtures of solutions of vancomycin and beta-lactam antibiotics have been shown to be physically incompatible In our present study, vancomycin TDM has been implemented, and dose adjustment was with the trough level 5 days post vancomycin initiation. A desired dose of 46.0 and 35.5 mg/kg/day were needed in patients with or without ARC, respectively, to reach the target trough levels of 10 mg/L

Description: Vancomycin is a glycopeptide antibiotic which binds tightly to D-alanyl-D-alanine portion of cell wall precursor, blocking glycopeptide polymerisation leading to the inhibition of bacterial cell wall synthesis.It also impairs bacterial-cell-membrane permeability and RNA synthesis. Pharmacokinetics: Absorption: Poorly absorbed from the gastrointestinal tract Take a trough sample (pre-dose) within 48 hours of starting therapy then every 2 to 3 days, or daily if the patient has unstable renal function. Monitor creatinine daily. Record the exact time of all vancomycin samples on the vancomycin prescribing chart AND on the sample request form Here is why giving one-dose vancomycin for SSTIs in stable patients is a bad idea: NO evidence that this shows any benefit. Not recommended by the Infectious Diseases Society of America (IDSA) 1. Extends the patient's ED stay by at least an hour for the IV infusion. Increases the cost of the ED visit (IV line, medication, RN time

New 2020 Vancomycin Dosing Guidelines: What Pharmacists

Compared with conventional-dose, loading dose of vancomycin can ensure the rapid achievement of target drug concentration and produce better antibacterial results. Effective control of infection might delay the progression of renal damage. Higher dose of vancomycin is also considered to cause other adverse effects This document is an executive summary of the new vancomycin consensus guidelines for vancomycin dosing and monitoring. It was developed by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists vancomycin consensus guidelines committee Vancomycin penetrates most tissues although its concentration is variable and often depends on the degree of inflammation present. Its penetration into the lung and central nervous system is poor, with a higher risk of subtherapeutic tissue concentration at lower doses. 5 Skin penetration is significantly lower in patients with diabetes when compared to patients without diabetes. Vancomycin concentrations achieved in serum in normal volunteers 2 hours after a single intravenous dose of 0.5 g and 1 g are about 10 µg/mL and 25 µg/mL, respectively. 56 These levels decrease to 2 µg/mL by 6 to 8 hours after 0.5 g and by 12 hours after 1 g. 56 Vancomycin pharmacokinetics in adults is best described by a two- or three. Vancomycin biodegradation was shown to be enhanced during ozonation of wastewater at 20 °C, pH 7.7 with 41, 68, 89, an 100% vancomycin transformation observed at applied ozone doses of 0.5, 1, 1,5, and 3 mg/L(1)

IV Vancomycin dosing and monitoring Antibiotic Guideline

  1. ing th
  2. al pain, and hypokalemia Label.In particular, incidences of hypokalemia, urinary tracy infection, peripheral edema, insomnia, constipation, anemia, depression.
  3. Diarrhea: Indications for Vancomycin Injection: Antibiotic-associated pseudomembranous colitis due to C. difficile. Adult Dosage: Dilute dose in 1oz of water and drink or give via nasogastric tube.
  4. The recommended dose of vancomycin in these guidelines is a fixed dose of 1000-1500 mg or a weight-adjusted dose of 10-15 mg/kg. The pharmacological properties of vancomycin are limited when compared with cephalosporins. In terms of microbiological and pharmacodynamics features,.
  5. Take vancomycin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Take vancomycin until you finish the prescription, even if you feel better. If you stop taking vancomycin too soon or miss doses, your infection may not be completely cured and bacteria may become resistant to antibiotics
  6. e by serum level... Hemodialysis. Not dialyzable. Deter
  7. imum inhibitory concentration for the organism at the site of action without significant systemic absorption.4,5 The literature does not support oral vancomycin

Vancomycin Dosing Guidelines What You Need To Know

Predicting the dose of vancomycin in ICU patients receiving different types of RRT therapy: a model-based meta-analytic approach. Guillaume Claisse, Service de Néphrologie, Dialyse, Transplantation Rénale, Hôpital Nord, Saint-Etienne, France. Search for more papers by this author Vancomycin can cause two types of hypersensitivity reactions, the red man syndrome and anaphylaxis. Red man syndrome has often been associated with rapid infusion of the first dose of the drug and was initially attributed to impurities found in vancomycin preparations. Even after improvement in vancomycin's purity, however, reports of the syndrome persist. Other antibiotics (e.g. ciprofloxacin. Owing to the narrow therapeutic index, dosing and monitoring of vancomycin have been subject of deliberation over the years. 3, 6, 12-17 Along with monitoring of drug concentration, individualized (personalized) dosing via PK tools have been suggested as an assisting tool to obtain a more precise PK target. 3, 6, 9, 12, 17-29 Vancomycin kinetics depends on two PK parameters: Volume of distribution (V) and elimination rate constant (K). To calculate an initial dose these parameters are estimated based on population kinetics. To calculate patient-specific V and K, at least two levels need to be drawn. In clinical practice a 'trough-only' approach is often used, but this only allows rough estimation of Vd, Ke, and AUC24 Pharmacokinetics and dose requirements of vancomycin in neonates C Grimsley, A H T Abstract Aims—To design and evaluate dosing guidelines for vancomycin based on data collected during routine use of the drug. Methods—Following the observation that 66% of neonatal vancomycin trough con-centrations were outside the target range

Infectious Disease Intern Lecture

Vancomycin Uses, Dosage, Side Effects - Drugs

Vancomycin Calculator - ClinCalc

Prevnar 13 - Bad Drug | Bad Drug

The Complete (but Practical) Guide to Vancomycin Dosing

  1. The recommended dose optimization was slightly higher than Neofax. We suggest a therapeutic range for vancomycin C ss,trough of 5-15 μg/mL, as this range was highly predictive of AUC 0-24 /MIC.
  2. istered dose of vancomycin is excreted in urine by glomerular filtration. Mean plasma clearance is about . 0.058 L/kg/h, and mean renal clearance is about 0.048 L/kg/h. Renal dysfunction slows excretion of vancomycin. In anephric patients, the average half-life of eli
  3. An initial high dose or high dose escalation can work best for Clostridium difficile treatment. Using an initial course of vancomycin or doing so in high dose escalation is often the most efficacious regimen for the treatment of Clostridium difficile ( C. difficile) diarrhea, according to new findings. Researchers from NYU Winthrop Hospital in.
  4. 5 to 20 mg/day intrathecally or intraventricularly is recommended; however, most studies have used a 10 mg or 20 mg dose.[32690] [61814] Use in addition to systemic vancomycin therapy. Adjust dose as necessary based on vancomycin CSF concentrations, MIC of the organism, ventricular size, and output from ventricular drain.[61814
  5. High dose of vancomycin plus gentamicin incorporated acrylic bone cement decreased the elution of vancomycin Tao Li,1,*, Lilan Fu,2,* Jian Wang,1 Zhanjun Shi11Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China; 2Nanfang PET Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic.

A higher dose of vancomycin is needed in critically ill

Vancomycin is an antibiotic. Oral (taken by mouth) vancomycin fights bacteria in the intestines. Vancomycin is used to treat an infection of the intestines caused by Clostridium difficile, which. DESCRIPTION. Vancomycin hydrochloride for injection, USP is a lyophilized powder, for preparing intravenous (IV) infusions, in vials each containing the equivalent of 500 mg, 750 mg, 1 g or 1.5 g vancomycin base. 500 mg of the base are equivalent to 0.34 mmol, 750 mg of the base are equivalent to 0.51 mmol, 1 g of the base are equivalent to 0.67 mmol and 1.5 g of the base are equivalent to 1. vancomycin dose of 20mg/kg intravenously over 2 hours (com - parison group). the initial dose was administered over 2 hours in both groups to preserve allocation concealment. All patients subse-quently received a 20mg/kg dose every 8 hours as was the stand - ard of care in our hospital for treatment of severe infections at the time of the study

Vancomycin Renal Dose Renal Function Impact, Body Weight

The ideal dosing regimen for vancomycin maximizes the amount of drug received. Therefore, the 24h-AUC/MIC ratio is the parameter that correlates with efficacy. For vancomycin, a 24h-AUC/MIC ratio of at least 125 is necessary (some researchers recommend a ratio of 400 or more for problem bugs). Vancomycin Outcome vs 24h-AUC/MIC ratio 1. Give loading dose of 25 mg/kg x 1 dose (max 2 g) 2. Check a vancomycin level at 24-48 hours post-dose or with am labs on the day of the next hemodialysis session (if applicable) to obtain an estimated steady state level a) High flux filters in HD will remove ~ 20-40% of the vancomycin dose during dialysis

Clinical Practice Guidelines : Vancomyci

Use Adjusted Body Weight for patients >120% of Ideal Body Weight. Recommend loading dose (20-25 mg/kg IV x1) for serious infections including CNS infections, endocarditis, pneumonia, bacteremia, osteomyelitis and sepsis. Use Vancomycin Dosing Calculator (Excel file) for more precise dose calculation and level-based adjustment Vancomycin inhibits transpeptidation by binding to D-alanyl-D-alanine residues of the bacterial cell wall. Pharmacodynamics Vancomycin commonly thought of as a time-dependant killer (T>MIC), however additional data suggests may also follow AUC:MIC Pharmacokinetics: Cmax: 18-26mg/L (after 15mg/kg dose) Half-life: 3-11 hour

Vancomycin Dosing in Hemodialysis — tl;dr pharmac

  1. g unit/g kill was 2.5 times higher for hVISA strains than for VISA and vancomycin-susceptible S. aureus strains. The research-ers concluded that vancomycin dosages of 500 mg every 6 hours or 1 g every 12 hours provide AUC/MIC values of f 100-250 and suggested that values around 500 may enhanc
  2. al pain.When vancomycin is taken by mouth, it stays in the intestines to stop the growth of bacteria that cause these symptoms.. This antibiotic treats only bacterial infection in the intestines
  3. vancomycin in the treatment of gram positive peri­ tonitis.4-6 The purpose of the current study was to compare IP conventional, continuous vancomycin therapy with two IP doses of vancomycin in the From the Departments of Nephrology and Microbiology, Prince Henry's Hospital, Melbourne, Australia
  4. Therapeutic monitoring of vancomycin: A revised consensus guideline and review 3 39 Background - Vancomycin has been in clinical use since 1958.Despite this vast clinical 40 experience with this agent, there are still major gaps in knowledge regarding the most 41 appropriate approach for optimizing patient therapy and avoiding potential adverse reactions
  5. The conventional dosing group was comprised of 65 patients who were treated with 125 mg oral vancomycin. They were clinically cured after an average of 5 days, after an average of 14 days of therapy. The second group, the high dose escalation group, had 33 patients who were originally treated with 250 mg vancomycin
  6. Vancomycin Pharmacology Made Easy. Vancomycin (Vancocin; FIRST-Vancomycin) is a drug used in the treatment of bacterial infections, often severe.It belongs to the glycopeptide drug class and has proved to be one of the most effective drugs in the treatment of many different infections
  7. The recommended vancomycin dose is 125 mg every 6 hours for 10 days for the first episode of non-severe CDI. This dose can be increased to 500 mg every 6 hours for 10 days in case of severe or complicated disease. The maximum daily dose should not exceed 2 g

Dose Optimization of Vancomycin Using a Mechanism-based

Vancomycin - StatPearls - NCBI Bookshel

November 24, 2015. More evidence is needed to figure out how to dose vancomycin in obese patients, but a new protocol could play a role. It's ok to give 1 g of vancomycin, as long as the patient is obese and the dosing interval is adjusted to follow the 2-compartment distribution model. Single, double, or triple A person who forgets to take a dose can take the missed dose unless it is almost time to take the next dose. If the time frame is too close, it is best to just skip the missed dose so as to avoid taking too much of the medication at one time. Also, to avoid a vancomycin overdose, the medication needs to be stored safely 4.2 Dose and method of administration . Dose . Adults . The usual intravenous dose is 500 mg every 6 hours or 1g every 12 hours. A 500 mg dose of vancomycin hydrochloride should be infused over a period of at least 60 minutes, whereas a 1 g dose should be administered over a period of at least 2 hours. Vancomycin must not be given b Intravenous vancomycin 30 mg/kg/dose once, followed 8 hours later by 20 mg/kg/dose every 8 hours. intravenous vancomycin hydrochloride: see description of study arms. Intravenous vancomycin 20 mg/kg/dose every 8 hours. intravenous vancomycin hydrochloride: see description of study arms. Total of all reporting groups

Antibiotic Ampicillin Sodium 125 mg / mL Injection Vial

Vancomycin Dosing & Monitoring Guideline

Vancomycin: Parenteral dosing, monitoring, and adverse

Vancomycin Loading Dose + vancomycin 15mg/kg (Especially if GPC on Gram stain of urine) Intra-Abdominal Infection • Piperacillin-tazobactam 4.5g IV Q8H extended infusion vancomycin 15mg/kg • Ertapenem 1g IV q24h • Aztreonam 2g iv q8h plus Metronidazole 500mg iv q8 In total joint arthroplasty (TJA), vancomycin is used as perioperative antibiotic prophylaxis in patients with penicillin allergy or in patients colonized with methicillin-resistant Staphylococcus aureus (MRSA). Although vancomycin dosing should be weight-based (15 mg/kg), not all surgeons are aware of this; a fixed 1-g dose is instead frequently administered This test is used to monitor levels of the antimicrobial drug vancomycin in the blood. After taking vancomycin, the amount in the blood rises for a period of time, peaks, and then begins to fall, usually reaching its lowest level, or trough, just before the next dose. The next dose is timed to coincide with the falling concentration of the drug in the blood They received vancomycin dose of 15 mg/kg every 8 h for mild infections or every 6 h if infection was moderate or severe. A nonlinear mixed-effects modeling approach was applied in estimating pharmacokinetic parameters using Monolix 2019R2®. We performed Monte Carlo simulations to assess and optimize the dosing regimen using Simulx® Vancomycin Hydrochloride for Injection, USP, is an off-white to buff-colored lyophilized powder, for preparing intravenous (IV) infusions, in Pharmacy Bulk Package bottles containing the equivalent of 5 g or 10 g vancomycin base. 500 mg of the base are equivalent to 0.34 mmol. When reconstituted with Sterile Water for Injection to a.

TeicoplaninAntibiotics in Oral and Maxillofacial SurgeryPart 2 - Aminoglycoside Vancomycin dosing

Vancomycin is an antibiotic used to treat diarrhea caused by intestinal infections from Clostridium difficile (C. Diff) and staphylococcal enterocolitis. Review side effects, dosages, drug interactions, and other safety information Vancomycin is a glycopeptide antibiotic derived from Amycolatopsis orientalis (formerly Nocardia orientalis). Vancomycin is bactericidal against many Gram -ve bacteria. It is used for suspected or proven MRSA infections or an infection caused by other organisms when sensitivity tests indicate no other antibiotic is available. Dose IV the infusion rate can allow vancomycin to be used safely. 5.2 When the infecting MRSA strain is known to have a vancomycin MIC >1.5 mcg/mL. 5.3 Single-dose procedural prophylaxis in patients known to be colonized with VRE or with an MRSA isolate with vancomycin MIC ≥2.0 mcg/mL, in a normally steril TDM after the first dose of antibiotic was adopted in our institution. This study aims to evaluate if target therapeutic drug concentrations could be achieved more rapidly in patients with TDM performed after the first dose of gentamicin, amikacin, or vancomycin compared to TDM at steady state Relationship of oral vancomycin prophylaxis (OVP) total daily dose to odds ratio (OR) for Clostridioides difficile infection (CDI). (A) Total daily dose of OVP was correlated to OR for CDI with R = 0.73 (right-hand side). This is also depicted on the left with faint blue arrows; as OVP total dose increased, CDI OR increased A one-time vancomycin loading dose of 25-30 mg/kg is recommended in the current iteration of the vancomycin consensus guidelines in order to more rapidly achieve target serum concentrations and hasten clinical improvement. However, there are few clinical data to support this practice, and the extents of its benefits are largely unknown. A multicenter, retrospective, cohort study was.

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